Salient points from Pediatric Neuro Conference today at Chennai Rain tree hotel
Epilepsy diagnosis is purely clinical and doesn't need a EEG.. As a normal eeg doesn't rule out epilepsy and an abnormal eeg doesn't conclude epilepsy..
If you are in doubt if it is epilepsy or syncope ask the history properly and EEG is not needed here to rule out epilepsy as we usually think
MRI is the investigation of choice and never a CT as radiation is soon high to cause leukemia s..
Treating epilepsy is not an emergency.. Only if you are sure about the diagnosis start AED s.. If u r in doubt wait for another episode to occur and then start .. If possible ask them to video record the event.. Though its practically tough insist the patient to do so as it is the best way to conclude seizure event.
Pseudo refractory seizures means trying 2 inappropriate combination of AED s and concluding that its a case of refractory seizures.. Always use the appropriate combinations..
Don't do MRI for Autism ADHD cases.. No need if MRI for absence seizures..
No role of Neuroimaging and EEG even in atypical febrile seizures.. No need of AED prophylaxis in any febrile seizure typical or atypical as it doesn't alter long term seizure occurrence.. Teaching parents to use midazolam nasal spray is all that is needed in most cases..
Don't increase AED s dose with increasing weight of child as we usually think .. If child is seizure free with that particular dose that's enough and continue with that alone..and don't increase dose for decreased serum drug levels of the drug.. Mostly serum drug levels don't have a role
No role of cannabinoid oil or L carnitine.. No use..in seizures
For Infantile spasms oral prednisone (40 mg per day for all ) is as good as ACTH .. ACTH has more complications..Prednisone can be combined with vigabatrin too..
Valproate causes asymptomatic increase in transaminase levels.. Not to be taken seriously until the AST ALT levels are increased more than 5 times the normal..
Epileptic surgery is not a last option as we think some epilepsy disorders improve well with surgery.. They are decided based on MRI.. Lesions which are predominantly on one side like mesial temporal sclerosis, heterotopia hemi megalencephaly, tuberous sclerosis sturge weber syndrome improve well with surgery..like lesionectomy lobectomy,hemispherectomy.
In certain rare MRI negative epilepsy usually cortical dysplasia s stereo EEG explorations could be done.. And the lesion causing seizure could be removed..
EEG machines made in India are of poor calibration and quality which gives you wrong diagnosis.. A EEG report should have the diagnosis and not merely cortical seizure activity or subcortical seizure activity ..
In all cases of acute transverse myelitis,, mri brain is a must along with spine so as not to miss a demyelination
Headaches in children.. First line of treatment is paracetamol and Ibubrufen( better option) .. Second line is triptans ( sumatriptan nasal spray) For a severe headache iv anti emetics are very useful.. Prophylaxis is for those with more than 3 attack s per month for past 3 months.. Propanolol is very good.. Flunarizine and Amitriptyline are good too but more side effects..Sodium valproate can also be used..good results.. Cyproheptadine is good for less than 6 years old children..
NCC and Tuberculoma.. How to differentiate❓..
NCC rule of 6 S.. Supratentorial, single,some edema, scolex, seizure only presentation, stage of lesion variable..
Tuberculoma can have features other than seizures like prolonged fever cough TB contact positive mantoux positivity.. Focal neurological deficit s, midline shift in MRI.. Multiple lesions..
Rarely both NCC and tuberculoma can coexist in the same patient..
Rarely multiple neurocysticercosis cysts can be seen in MRI disseminated ones... Called as starry sky appearance...can present with fever vomiting headache etc..
No role of MRI spectroscopy with lipid peak and lactate peaks in differentiating both..
Duchene muscular dystrophy.. Treatment is Prednisone 0.75 mg per kg per day...or Deflazocort 0.9 mg per kg per day.. Prednisone has high risk of obesity.. Deflazocort has high risk of cataract..
Two drugs with same mechanism of action is an inappropriate combination egs. Phenytoin and Carbamazepine , Phenytoin and valproate...
Those with different mechanism of action is a good combination.. E.g.Valproate and Lamotrigine, Valproate and leviteracetam, Leviteracetam and clobazam, Valproate and clobazam, ..
Nowadays neurologists prescriptions have Valproate+ clobazam or Leviteracetam+ clobazam.. This combination works well I guess😊
Few points to add to pearls:
Levitiractetam - not much effective in continuous , daily, multiple seizures. Lamotrigine, topiramate are better options.
2. Clobazam - best first add on drug in seizures not controlled with a single drug.
3.valproate not effective in focal seizures.
4.clobazam and PBT need a slow tapering